A plasmid DNA cancer vaccine encoding the intracellular domain (ICD) of the HER-2/neu proto-oncogene. Upon administration and after cellular uptake by skin or … [Read more...]
Search Results for: Tumor
PARP1 inhibitor PF-01367338
A tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. PARP-1 … [Read more...]
MEK inhibitor GDC-0973
An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK … [Read more...]
piritrexim
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby … [Read more...]
mapatumumab
A fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) with apoptosis promoting and … [Read more...]
Pim kinase inhibitor SGI-1776
A small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of … [Read more...]
NMPRTase inhibitor APO866
A small molecule with potential antineoplastic and antiangiogenic activities. NMPRTase inhibitor APO866 binds to and inhibits nicotinamide … [Read more...]
monoclonal antibody m170
A panadenocarcinoma murine monoclonal antibody with potential antineoplastic activity. Monoclonal antibody m170 may be conjugated with a radioactive element … [Read more...]
maytansine
An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby … [Read more...]
PI3K inhibitor GDC-0941 bismesylate
The orally bioavailable bismesylate salt of a potent small-molecule thieno[3,2-d]pyrimidine inhibitor of the class I phosphatidylinositol 3 kinase (PI3K) … [Read more...]