human MHC non-restricted cytotoxic T-cell line TALL-104

Definition / meaning of human MHC non-restricted cytotoxic T-cell line TALL-104

An allogeneic human cytotoxic T-lymphocyte cell line with potential antineoplastic activity. Human MHC non-restricted cytotoxic T-cell line TALL-104 is an IL-2-dependent human leukemic T cell line, expressing CD8 and CD3 but not CD16. Upon administration, human MHC non-restricted cytotoxic T-cell line TALL-104 interacts with tumor cells and activates apoptotic and necrotic pathways, resulting in tumor cell lysis. Endowed with MHC-non-restricted killer activity, these cells are cytotoxic against a broad range of tumor cells, sparing normal cells. In addition, TALL-104 may induce secretion of various cytokines, such as interferon-gamma, potentially enhancing its cytotoxic activity.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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