HLA-A2, A3-restricted FGF-5 peptides / Montanide ISA-51 vaccine

Definition / meaning of HLA-A2, A3-restricted FGF-5 peptides / Montanide ISA-51 vaccine

A peptide vaccine comprised of synthetic HLA-A2- and HLA-A3-binding peptides, derived from amino acid sequences of fibroblast growth factor-5 (FGF-5), combined with the adjuvant Montanide ISA-51 with potential antineoplastic activity. HLA-A2, A3-restricted FGF-5 peptides contain motifs recognized by the MHC class I molecules HLA-A2 and HLA-A3 and may stimulate a cytotoxic T-cell response against tumor cells that overexpress FGF-5. Montanide ISA-51 (also known as incomplete Freund’s adjuvant or IFA), a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant, non-specifically stimulates cell-mediated immune responses to antigens.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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