hepsulfam

Definition / meaning of hepsulfam

A bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents. Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity.

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Find More About 'hepsulfam'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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