MVA-PSA-PAP prostate cancer vaccine

Definition / meaning of MVA-PSA-PAP prostate cancer vaccine

A cancer vaccine consisting of a recombinant modified vaccinia Ankara (MVA) viral vector encoding genes for prostate specific antigen (PSA) and prostate acid phosphatase (PAP) with potential immunostimulatory and antineoplastic activities. Upon administration, MVA-PSA-PAP prostate cancer vaccineexpresses PSA and PAP peptides, which may elicit humoral and cellular immune responses against prostate cancer cells expressing PSA and PAP. Multi-antigen vaccine therapy may be more efficacious than single-antigen therapy vaccine therapy.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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