multikinase inhibitor SAR103168

Definition / meaning of multikinase inhibitor SAR103168

A multikinase inhibitor with potential antineoplastic activity. Upon intravenous infusion, multikinase inhibitor SAR103168 may, through the inhibition of multiple kinases, inhibit the phosphorylation and activation of signal transducer and activator of transcription 5 (STAT5). STAT5, a protein often upregulated in cancer cells, plays a key role in signal transduction pathways and the suppression of apoptosis.

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The Web site of the National Cancer Institute (http://www.cancer.gov/)

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