MUC-1 peptide vaccine

Definition / meaning of MUC-1 peptide vaccine

A cancer vaccine comprised of a synthetic peptide derived from the mucin 1 (MUC-1) antigen with potential antineoplastic activity. Upon administration, MUC-1 peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the MUC-1 antigen, resulting in decreased tumor growth. Overexpressed by many tumor cell types, MUC-1 antigen, a mammary-type apomucin, is a high-molecular-weight transmembrane glycoprotein.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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