MOv-gamma chimeric receptor gene

Definition / meaning of MOv-gamma chimeric receptor gene

A recombinant engineered chimeric gene derived from the murine gene encoding the variable region of monoclonal antibody MOv18 against folate-binding protein, which is often overexpressed in human ovarian cancer cells, and the gene encoding the Fc receptor for the gamma subunit of human IgG and IgE. Peripheral blood lymphocytes expressing the MOv-gamma gene may be used in the immunotherapeutic treatment of ovarian cancer.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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