monoclonal antibody HuM291

Definition / meaning of monoclonal antibody HuM291

A humanized monoclonal antibody deficient in Fc receptor binding directed against CD3 on the surfaces of T cells. Monoclonal antibody HuM291 binds to the CD3 portion of the CD3:TCR (T-cell receptor) complex expressed on the surface of T cells, resulting in apoptosis of antigen-activated T cells.,

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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