monoclonal antibody GD2 anti-idiotype vaccine

Definition / meaning of monoclonal antibody GD2 anti-idiotype vaccine

A class of vaccines that consist of anti-idiotype monoclonal antibodies against the tumor-associated antigen disialoganglioside GD2 with potential antineoplastic activity. Vaccination with a monoclonal antibody GD2 anti-idiotype vaccine produces an immunoglobulin response against GD2 with subsequent destruction of GD2 positive tumor cells via antibody-dependent cellular cytotoxicity (ADCC). GD2 is overexpressed in melanoma, neuroblastoma, soft tissue sarcoma, and small cell carcinoma of the lung.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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