monoclonal antibody A33

Definition / meaning of monoclonal antibody A33

A humanized monoclonal antibody directed against the human A33 antigen. Monoclonal antibody A33 recognizes the human A33 antigen, a 43 KDa transmembrane glycoprotein of the immunoglobulin superfamily, which is highly and homogenously expressed in 95% of colorectal cancer metastases with only restricted expression in normal colonic mucosa.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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