monoclonal antibody 14G2A

Definition / meaning of monoclonal antibody 14G2A

A murine monoclonal antibody directed against the ganglioside GD2 with potential antineoplastic activity. Monoclonal antibody 14G2A binds to the ganglioside GD2 and induces antibody-dependent cell mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells. GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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