mitotane

Definition / meaning of mitotane

A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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