misonidazole

Definition / meaning of misonidazole

A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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