metoprine

Definition / meaning of metoprine

A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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