methoxyamine

Definition / meaning of methoxyamine

An orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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