melphalan

Definition / meaning of melphalan

An orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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