malignant glioma tumor lysate-pulsed autologous dendritic cell vaccine

Definition / meaning of malignant glioma tumor lysate-pulsed autologous dendritic cell vaccine

A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with lysates from malignant glioma cells with potential immunostimulatory and antineoplastic activities. Upon administration, malignant glioma tumor lysate-pulsed autologous dendritic cell vaccine exposes the immune system to undefined malignant glioma tumor-associated antigens (TAAs), which may result in anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against glioma cells and glioma cell lysis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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