hypoxia-activated prodrug TH-302

Definition / meaning of hypoxia-activated prodrug TH-302

A hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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