human gp100 plasmid DNA vaccine

Definition / meaning of human gp100 plasmid DNA vaccine

A vaccine consisting of a plasmid DNA encoding the human melanoma-associated antigen gp100. Upon adminsistration, expressed gp100 antigen may stimulate a cytotoxic T cell HLA-A2.1-restricted immune response against tumor cells that express this antigen, resulting in tumor cell lysis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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