zoledronic acid

Meaning of zoledronic acid: Zoledronic acid is an intravenous bisphosphonate used to treat cancer-related high blood calcium and to reduce fractures from bone metastases.

Definition of zoledronic acid

Zoledronic acid is a medication belonging to the bisphosphonate class, given by intravenous infusion, used mainly to treat hypercalcemia, an elevated level of calcium in the blood, that occurs as a complication of certain cancers. It works by slowing the activity of the cells responsible for breaking down bone, which reduces the release of calcium from bone into the bloodstream.

Zoledronic acid is also used, often alongside other treatment, in people with multiple myeloma or with cancer that has spread to the bone, where it helps reduce the risk of fractures and other bone complications and can lessen bone pain related to cancer involvement of the skeleton.

Because zoledronic acid affects bone remodeling throughout the body, its use requires attention to kidney function and to dental health, since bisphosphonates as a class have been associated with rare complications affecting the jaw when bone healing is impaired. It is also known as zoledronate or by the brand name Zometa.