Definition / meaning of zinostatin

An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis.

Listed under:

Find More About 'zinostatin'


The Web site of the National Cancer Institute (http://www.cancer.gov/)

Leave a Comment


This site uses Akismet to reduce spam. Learn how your comment data is processed.