Search Results for: Minor

DNA minor groove-binding agent PM01183

A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. DNA minor groove-binding agent PM01183 … [Read more...]


An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove … [Read more...]


A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to … [Read more...]

inotuzumab ozogamicin

A CD22-targeted cytotoxic immunoconjugate composed of a humanized IgG4 anti-CD22 antibody covalently linked to N-acetyl-gamma-calicheamicin dimethyl hydrazide … [Read more...]

chromomycin A3

A glycosidic antineoplastic antibiotic isolated from the bacterium Streptomyces griseus. Chromomycin A3 reversibly binds to guanine-cytosine (G-C) base pairs … [Read more...]

anti-CD70 antibody-drug conjugate MDX-1203

An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed against the extracellular domain of the human CD70 molecule, conjugated … [Read more...]


A legal document in which a person states what is to be done with his or her property after death, who is to carry out the terms of the will, and who is to care … [Read more...]


A synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin … [Read more...]

calendula ointment

A substance made from the flower of the marigold plant Calendula officinalis. Calendula-based skin products have been used to treat minor cuts, burns, and skin … [Read more...]

brostallicin hydrochloride

A substance being studied in the treatment of cancer. Brostallicin hydrochloride binds to DNA and may kill cancer cells. It may also help other drugs kill … [Read more...]