MedicalTerminology DB

Meaning of PSA failure: A rise in the blood level of PSA (prostate-specific antigen) in prostate cancer patients after treatment with surgery or radiation.

Definition of PSA failure

A rise in the blood level of PSA (prostate-specific antigen) in prostate cancer patients after treatment with surgery or radiation. PSA failure may occur in patients who do not have symptoms. It may mean that the cancer has come back. Also called biochemical recurrence and biochemical relapse.

Written and maintained by James Murray Last updated July 21, 2026 Educational reference, not medical advice. Read the limitations.

For learning, not diagnosis. This glossary provides general educational information and is not a substitute for advice from a qualified healthcare professional. If you may be experiencing a medical emergency, contact local emergency services.