MedicalTerminology DB

1 Definition of PPI-2458

Meaning of PPI-2458: A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties.

A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.

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