paclitaxel vitamin E-based emulsion formulation

Definition / meaning of paclitaxel vitamin E-based emulsion formulation

A cremophor-free, P-glycoprotein-inhibiting, vitamin E-based emulsion particle formulation of paclitaxel with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). The vitamin-E based emulsion allows bolus infusion without steroid premedication and may diminish hypersensitivity reactions; tumor tissue may be passively targeted due to preferential deposition of emulsion particles while an emulsion formulation component inhibits the P-glycoprotein drug efflux pump.

Listed under:

Find More About 'paclitaxel vitamin E-based emulsion formulation'


The Web site of the National Cancer Institute (

Leave a Comment


This site uses Akismet to reduce spam. Learn how your comment data is processed.