oxaliplatin

Meaning of oxaliplatin: This chemotherapy drug is notable for a distinctive nerve related side effect that can be triggered or worsened by exposure to cold.

Definition of oxaliplatin

Oxaliplatin is a platinum containing chemotherapy drug belonging to the same general drug family as cisplatin and carboplatin, developed as a later generation option within this class. It is used primarily to treat colorectal cancer, generally given in combination with other chemotherapy drugs as part of a multi-drug regimen, and administered by intravenous infusion.

Oxaliplatin works by binding directly to a cancer cell's DNA, forming crosslinks between strands of the genetic material that prevent the cell from properly copying its DNA and dividing. This disruption of normal DNA replication ultimately leads to the death of cells that are actively dividing, including cancer cells.

A distinctive feature of oxaliplatin, setting it apart from other platinum based chemotherapy drugs, is a nerve related side effect that can be brought on or made worse by exposure to cold, causing sensations such as tingling or discomfort in the hands, feet, or throat, an effect generally managed by avoiding cold exposure during and shortly after treatment.