opioid growth factor

Definition / meaning of opioid growth factor

An endogenous pentapeptide with potential antineoplastic and antiangiogenic activities. Opioid growth factor (OGF) binds to and activates the opioid growth factor receptor (OGFr), present on some tumor cells and vascular cells, thereby inhibiting tumor cell proliferation and angiogenesis.

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The Web site of the National Cancer Institute (http://www.cancer.gov/)

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