Definition / meaning of N-phosphonacetyl-L-aspartate

A stable transition state analogue for an aspartate transcarbamylase- cartalyzed reaction with antineoplastic activity. N-phosphonacetyl-L-aspartate (PALA) is a stable transition analogue of the activated complex for the reaction catalyzed by aspartate transcarbamylase, the first step in the pyrimidine biosynthetic pathway. This agent inhibits de novo pyrimidine biosynthesis and increases the extent to which fluorouracil metabolites are incorporated into RNA.

Listed under:

Find More About 'N-phosphonacetyl-L-aspartate'


The Web site of the National Cancer Institute (http://www.cancer.gov/)

Leave a Comment


This site uses Akismet to reduce spam. Learn how your comment data is processed.