lyso-thermosensitive liposome doxorubicin

Definition / meaning of lyso-thermosensitive liposome doxorubicin

A temperature-sensitive liposomal formulation of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Upon intravenous administration, circulating thermosensitive liposomes are activated locally by increasing the tumor temperature to 40-41 degrees Celsius using an external heat source. The elevated temperature causes compositional changes in the liposomes, creating openings that allow for the release of encapsulated doxorubicin. Compared to non-thermosensitive liposomes, lyso-thermosensitive liposomes deliver higher concentrations of a cytotoxic agent to a heat-treated tumor site while sparing normal tissues unexposed to heat treatment.

Listed under:

Find More About 'lyso-thermosensitive liposome doxorubicin'


The Web site of the National Cancer Institute (

Leave a Comment


This site uses Akismet to reduce spam. Learn how your comment data is processed.