MedicalTerminology DB

Meaning of Li-Fraumeni syndrome: A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene.

Definition of Li-Fraumeni syndrome

A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene.

Written and maintained by James Murray Last updated July 21, 2026 Educational reference, not medical advice. Read the limitations.

For learning, not diagnosis. This glossary provides general educational information and is not a substitute for advice from a qualified healthcare professional. If you may be experiencing a medical emergency, contact local emergency services.