ixabepilone

Definition / meaning of ixabepilone

An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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