ipilimumab

Definition / meaning of ipilimumab

A monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen-4 (CTLA4), an antigen that is expressed on activated T-cells and exhibits affinity for B7 co-stimulatory molecules. By binding CTLA4, ipilimumab enhances T-cell activation and blocks B7-1 and B7-2 T-cell co-stimulatory pathways.

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Find More About 'ipilimumab'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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