elsamitrucin

Definition / meaning of elsamitrucin

A heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication.

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Find More About 'elsamitrucin'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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