EKB-569

Definition / meaning of EKB-569

A 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. EKB-569 irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors.

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Find More About 'EKB-569'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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