Home/Topics/Cancer & Tumors/Clark level IV melanoma Cancer & Tumors Cancer & Oncology Skin, Hair & Nails Clark level IV melanoma Listen Save Share Print Meaning of Clark level IV melanoma: Melanoma that has spread down into the reticular dermis (the thick bottom layer of the dermis). Definition of Clark level IV melanoma Melanoma that has spread down into the reticular dermis (the thick bottom layer of the dermis). Written and maintained by James Murray · Last updated July 21, 2026 Educational reference, not medical advice. Read the limitations. Keep exploringRelated termsMore in Cancer & Tumors → Cancer & Tumors melanoma Far less common than the everyday skin cancers but responsible for most deaths from them, because it spreads while it is still small. Read definition → Cancer & Tumors skin cancer One label covers several different diseases, and which cell a tumor came from matters far more than the fact that it sits in skin. Read definition → Cancer & Tumors amelanotic melanoma Amelanotic melanoma is a form of skin cancer that lacks the dark pigment typical of melanoma, often appearing pink or red instead. Read definition → Cancer & Tumors hairy cell leukemia A slow-growing blood cancer named for the fringed look of its cells, marked by a large spleen and low counts across the board. Read definition →
Cancer & Tumors melanoma Far less common than the everyday skin cancers but responsible for most deaths from them, because it spreads while it is still small. Read definition →
Cancer & Tumors skin cancer One label covers several different diseases, and which cell a tumor came from matters far more than the fact that it sits in skin. Read definition →
Cancer & Tumors amelanotic melanoma Amelanotic melanoma is a form of skin cancer that lacks the dark pigment typical of melanoma, often appearing pink or red instead. Read definition →
Cancer & Tumors hairy cell leukemia A slow-growing blood cancer named for the fringed look of its cells, marked by a large spleen and low counts across the board. Read definition →