c-Met inhibitor JNJ-38877605

Definition / meaning of c-Met inhibitor JNJ-38877605

An orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. c-Met inhibitor JNJ-38877605 selectively inhibits c-Met (mesenchymal-epithelial transition), a receptor tyrosine kinase (RTK) involved in cancer cell survival and invasiveness, and tumor angiogenesis.c-Met is also known as hepatocyte growth factor receptor (HGFR).

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The Web site of the National Cancer Institute (http://www.cancer.gov/)

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