biricodar dicitrate

Definition / meaning of biricodar dicitrate

The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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