ARRY-334543

Definition / meaning of ARRY-334543

An orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. ARRY-334543 selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.

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Find More About 'ARRY-334543'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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