apoptosis inducer GCS-100

Definition / meaning of apoptosis inducer GCS-100

A galectin-binding polysaccharide derived from citrus pectin with potential antineoplastic activity. Apoptosis inducer GCS-100 binds to the carbohydrate-binding domain of the lectin galectin-3, which may result in apoptosis mediated through mitochondria/caspase activation cascades; this agent may overcome tumor growth mediated through anti-apoptotic protein Bcl-2, heat shock protein-27 (Hsp-27), and nuclear factor-kappa B (NF-kB). Galectin-3, a chimeric molecule consisting of bothcarbohydrate recognition and collagen-like domains, interacts with a variety of carbohydrate andprotein ligands to form pentamers with uniquecrosslinking abilities; this lectin also exhibits anti-apoptotic properties, perhaps, in part, through the regulation of intracellular signaling pathways.

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The Web site of the National Cancer Institute (http://www.cancer.gov/)

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