anti-1-amino-3-[18F ]fluorocyclobutane-1-carboxylic acid

Definition / meaning of anti-1-amino-3-[18F ]fluorocyclobutane-1-carboxylic acid

A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid ([18]FACBC) appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occuring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, [18]FACBC accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET).

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