4-nitroestrone 3-methyl ether

Definition / meaning of 4-nitroestrone 3-methyl ether

A synthetic derivative of estradiol. 4-nitroestrone 3-methyl ether inhibits estrogen sulfotransferase (EST), a progesterone-induced secretory endometrial enzyme which affects estrogen receptor levels. This agent has been shown to be an effective growth inhibitor of some chemically induced animal mammary tumors.

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The Web site of the National Cancer Institute (http://www.cancer.gov/)

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