zosuquidar trihydrochloride

Definition / meaning of zosuquidar trihydrochloride

A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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