zibotentan

Definition / meaning of zibotentan

An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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