yttrium Y 90 epratuzumab

Definition / meaning of yttrium Y 90 epratuzumab

A radioimmunoconjugate consisting of the anti-CD22 monoclonal antibody epratuzumab chelated to the radioisotope yttrium-90 (Y 90). Yttrium Y 90 epratuzumab binds to tumor cells expressing CD22, delivering a cytotoxic dose of beta radiation. Epratuzumab is a humanized version of the murine monoclonal antibody LL2; CD22 is a B cell-restricted antigen present on the surfaces of mature B cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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