yttrium Y 90 DOTA monoclonal antibody HuPAM4

Definition / meaning of yttrium Y 90 DOTA monoclonal antibody HuPAM4

A radioimmunoconjugate comprised of the humanized monoclonal antibody HuPAM4, directed against the pancreatic cancer antigen MUC1, that is conjugated to the chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope Yttrium Y90. Yttrium Y 90 DOTA monoclonal antibody HuPAM4 binds to tumor cells expressing MUC1 antigen, selectively delivering a cytotoxic dose of beta radiation.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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