yttrium Y 90 DOTA monoclonal antibody HuAFP31

Definition / meaning of yttrium Y 90 DOTA monoclonal antibody HuAFP31

A radioimmunoconjugate comprised of the monoclonal antibody HuAFP31, directed against alpha fetoprotein, that is conjugated to the chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope Yttrium Y90. Yttrium Y 90 DOTA monoclonal antibody HuAFP31 binds to tumor cells expressing alpha fetoprotein, selectively delivering a cytotoxic dose of beta radiation.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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