yttrium Y 90-DOTA-chimeric monoclonal antibody cG250

Definition / meaning of yttrium Y 90-DOTA-chimeric monoclonal antibody cG250

A radioimmunoconjugate comprised of the chimeric monoclonal antibody cG250 conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and lableled with the beta-emitting radioisotope yttrium Y 90. The antibody moiety of yttrium Y 90 DOTA chimeric monoclonal antibody cG250 binds to renal cell carcinoma cells expressing the G250 antigen, thereby selectively delivering a cytotoxic dose of beta radiation.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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