Definition / meaning of TRAIL-R1

A protein on the surface of certain cells that binds another protein called TRAIL, which may kill some cancer cells. An increase in the amount or activity of TRAIL-R1 on cancer cells may kill more cells. Also called death receptor 4, DR4, TRAIL receptor 1, and tumor necrosis factor receptor superfamily member 10A.

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The Web site of the National Cancer Institute (

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