topoisomerase inhibitor

Definition / meaning of topoisomerase inhibitor

A substance that blocks topoisomerases (enzymes that break and rejoin DNA strands and are needed for cells to divide and grow). Blocking these enzymes may kill cancer cells. Certain topoisomerase inhibitors are being studied in the treatment of cancer.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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